Genetic, clinical and radiographic signs in knee osteoarthritis susceptibility
نویسندگان
چکیده
منابع مشابه
Genetic, clinical and radiographic signs in knee osteoarthritis susceptibility
INTRODUCTION Osteoarthritis (OA) is considered to be a multifactorial and polygenic disease and diagnosis is mainly clinical and radiological. Correlation between radiographic data and clinical status has been reported. However, very few studies, especially in Caucasian people, describe the association between the Kellgren and Lawrence OA grading scale (KL) and genetic alterations to better und...
متن کاملGenetic contribution to radiographic severity in osteoarthritis of the knee
OBJECTIVE Knee osteoarthritis (OA) has a significant genetic component. The authors have assessed the role of three variants reported to influence risk of knee OA with p<5×10-8 in determining patellofemoral and tibiofemoral Kellgren Lawrence (K/L) grade in knee OA cases. METHODS 3474 knee OA cases with sky-line and weight-bearing antero-posterior x-rays of the knee were selected based on the ...
متن کاملConcordance between clinical and radiographic evaluations of knee osteoarthritis
BACKGROUND Significant correlation has been previously demonstrated between radiographic and clinical diagnoses of knee osteoarthritis (OA); however, the specific findings on clinical examination that relate best to a radiographic diagnosis have not been fully elicited. AIMS We aimed to explore the relationship between clinical symptoms and physical findings with radiographic diagnoses of tib...
متن کاملDo clinical findings associate with radiographic osteoarthritis of the knee?
From a population survey of 2865 subjects, test characteristics of a number of clinical findings relating to knee osteoarthritis were calculated against the standard of radiographic diagnosis. The clinical findings included from the history were age, gender, current pain in the knee, swollen knee, pain in both hands, morning stiffness, osteoarthritis in any joint, pain or stiffness, or both, in...
متن کاملFactors affecting radiographic progression of knee osteoarthritis.
OBJECTIVES To evaluate the prognostic significance of patient characteristics and radiographic features at the knee for outcome of knee osteoarthritis. METHODS This was a prospective observational study of 350 osteoarthritic knees. Clinical and radiographic data were obtained on 188 hospital referred patients (mean age 70, range 34-91 years). RESULTS Median duration of follow up was two yea...
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ژورنال
عنوان ژورنال: Arthritis Research & Therapy
سال: 2014
ISSN: 1478-6354
DOI: 10.1186/ar4535